CBG vs CBD: What are the differences?
CBG vs CBD: What are the differences?
Produkte, die Cannabidiol (CBD) enthalten, haben in den letzten Jahren explosionsartig an Popularität gewonnen, da die angeblich entzündungshemmende und antioxidative Wirkung des Cannabinoids es zu einer trendigen Zutat für Produkte ist. Wobei Cannabis mit THC im medizinischen Bereich sehr gute Akzeptanz findet.
Als der wichtigste nicht toxische Bestandteil von Cannabis ist CBD in den gängigen Cannabis-Sorten ziemlich häufig anzutreffen, so dass die Isolierung und der Gebrauch des Cannabinoids leicht auf die Herstellung kommerzieller Produkte übertragen werden kann.
Doch seit kurzem macht ein anderes nicht toxisches Cannabinoid als potenzielles therapeutisches Produkt Schlagzeilen. Cannabigerol (CBG) ist ein weniger häufig vorkommendes Cannabinoid, aber es wurde beobachtet, dass es Entzündungen lindert, Schmerzen bekämpft und sogar .
CBG mag oberflächlich betrachtet ähnlich klingen wie CBD, aber wenn man etwas tiefer gräbt, lassen sich wesentliche Unterschiede finden.
Products containing cannabidiol (CBD) have exploded in popularity in recent years as the alleged anti-inflammatory and antioxidant properties of cannabinoid make it a trendy ingredient for products. Whereby cannabis containing THC is very well accepted in the medical field.
As the most important non-toxic component of cannabis, CBD is quite common in common cannabis strains, so the isolation and use of the cannabinoid can easily be transferred to the production of commercial products.
However, recently another non-toxic cannabinoid has been making headlines as a potential therapeutic product. Cannabigerol (CBG) is a less common cannabinoid, but it has been observed to relieve inflammation, combat pain and even slow down the proliferation of some cancer cells.
CBG may sound similar to CBD on the surface, but if you dig a little deeper, you will find significant differences.
What is CBG? – CBG vs CBD: What are the differences?
In the first two parts of this series on the chemistry of cannabis, CBDA vs CBD: What are the differences? and THCA vs THC: What are the differences?, it was explained how all cannabinoids contained in cannabis are derived from cannabigerolic acid (CBGA).
Conversion of cannabigerolic acid (CBGA) into cannabigerol (CBG) and cannabidiol (CBD) via cannabidiol acid (CBDA)
When the cannabis plant matures, CBGA, the acid form of CBG, is converted by plant enzymes into a certain ratio of the three major cannabinoid precursors: tetrahydrocannabic acid (THCA), cannabidiol acid (CBDA) and cannabichromenic acid (CBCA).
From the amounts of CBGA that are not converted into these precursors or any of the other smaller cannabinoids, CBG is formed by decarboxylation.
As a result of this process, cannabis strains usually contain very little CBG, often less than 1% by weight. In order to achieve higher yields of CBG in cannabis, specialized plant breeders have started experimenting with genetic manipulation and crossbreeding. Leafly reports that scientists have also successfully identified the optimal extraction window for cannabis to obtain the highest levels of CBG, and recommends that extraction be performed approximately six weeks after an eight-week flowering cycle.
CBG advantages – CBG vs CBD: What are the differences?
In contrast to the CBD, which has a relatively low affinity to cannabinoid receptors and acts mainly through indirect interactions with the endocannabinoid system, the CBG is believed to directly elicit its therapeutic effect, although interaction with CB1 and CB2 cannabinoid receptors in the brain.
The psychoactive cannabinoid THC also produces its psychoactive effects through interactions with these receptors; it has been observed that CBG acts as a buffer for the psychoactivity of THC and may even relieve the feeling of paranoia sometimes associated with the consumption of high THC concentrations.
Research is relatively sparse as to the therapeutic benefits of CBG when compared to the apparent wealth of information available within the cannabis scientific community about THC and CBD. However, there are early studies that link the compound to a whole range of potential therapeutic applications, such as
- Treatment of glaucoma, through its vasodilating and neuroprotective effects.
- Decreasing inflammation, as seen in animal models of inflammatory bowel disease
- Treatment of Huntingdon disease, again through its neuroprotective effect
- Inhibition of tumor growth, as seen in animal models of colon cancer
- Killing drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA).
The difficulties in the production of CBG -CBG vs CBD: What are the differences?
Why hasn’t the CBG, which has no intoxicating effect and offers a large number of potential therapeutic applications, experienced the same surge in popularity as the CBD?
The biggest stumbling block for the realization of CBG as a common therapeutic treatment is the production costs. CBG is believed to produce one of the most expensive cannabinoids, so much so that it has been called “the Rolls-Royce of cannabinoids”.
“It takes thousands of pounds of biomass to produce small amounts of CBG isolate,” said James Rowland, CEO of Colorado-based CBG brand Steve’s Goods. Forbes.
“This is because most hemp contains only small amounts of CBG, while today there are hemp varieties that contain 20 percent CBD in the crop. If the CBG content of the same crop is only 1 percent, that means you have to extract 20 times the amount of biomass to get the same amount of CBG out.
CBG is also a problem for growers. The longer a cannabis plant matures, the greater the likelihood that the CBGA and CBG present in the strain will be converted into other cannabinoids. This presents growers with a choice: either they grow cannabis with the express purpose of producing CBG, which means that they can harvest the plant early, before this conversion is complete, or they let the plant mature completely, so that part of the plant can be sold for other purposes, but the rest has a lower CBG content for extraction.
Compared to THC or CBD extraction, CBG extraction requires not only larger quantities of plant material, but also the use of special production equipment. Due to the low CBG content in cannabis strains, the chromatography equipment used for the isolation and purification of CBG extracts must be as precise as possible in order to avoid using more raw cannabis or hemp material than absolutely necessary. The cost of this high performance chromatography instrument can result in high up-front production costs for processors who do not already use this instrument in their standard processing procedures.
“Cannabinoid-specific markets will continue to fluctuate sharply for several years until demand balances,” Rowland added. “I think it will remain considerably more expensive than the CBD for a long time to come, but as CBD prices fall, you will see CBG prices fall”.
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